The Microbiome
How Diet and the Intestinal Microbiome Act as Modulators of Breast Malignancy
"The intestinal microbiome plays an important role in human physiology. Dysbiosis is the disturbed microbiome ecology secondary to external pressures such as host diseases, medications, diet and genetic conditions often leading to abnormalities of the host immune system.
Specifically dysbiosis has been shown to lower circulating lymphocytes, and increase neutrophil to lymphocyte ratio, a finding which has been associated with a decreased survival in women with breast cancers. Dysbiosis also plays a role in the recycling of estrogens via the entero-hepatic circulation, increasing estrogenic potency in the host, which is another leading cause of breast malignancy."
So state researchers from Hofstra North Shore Long Island Jewish School of Medicine.
Click here to read their study, published in the September, 2013 issue of the Journal, "Oncology."
Specifically dysbiosis has been shown to lower circulating lymphocytes, and increase neutrophil to lymphocyte ratio, a finding which has been associated with a decreased survival in women with breast cancers. Dysbiosis also plays a role in the recycling of estrogens via the entero-hepatic circulation, increasing estrogenic potency in the host, which is another leading cause of breast malignancy."
So state researchers from Hofstra North Shore Long Island Jewish School of Medicine.
Click here to read their study, published in the September, 2013 issue of the Journal, "Oncology."
The Gut-Brain Connection, Mental Illness, and Disease
"On our skin, in our gums, and in our guts live 100 trillion organisms, altogether known as the microbiome. These beasties comprise 90% of the cells of our bodies
All in all, the gut is a terrific place to start helping humans be as healthy, resilient, and robust as we have evolved to be.
What do they have to do with psychiatry? It turns out way more than we might have suspected. The gut and brain have a steady ability to communicate via the nervous system, hormones, and the immune system. Some of the microbiome can release neurotransmitters, just like our own neurons do, speaking to the brain in its own language via the vagus nerve.
To have a full understanding of how the whole gut-brain connection works, you need robust knowledge of endocrinology, immunology, pathology, and neurology, which is a bit beyond the scope of a blog article. However, to break it down to simplistic terms, here are the basic links:"
Germ theory is dead. We are more germ than human.
Click here to read the entire article by Dr. Emily Deans published on the website of "Psychology Today" in April, 2014.
"Mammals live in a co-evolutionary association with the plethora of microorganisms that reside at a variety of tissue microenvironments. The microbiome represents the collective genomes of these co-existing microorganisms, which is shaped by host factors such as genetics and nutrients but in turn is able to influence host biology in health and disease. Niche-specific microbiome, prominently the gut microbiome, has the capacity to effect both local and distal sites within the host. The gut microbiome has played a crucial role in the bidirectional gut–brain axis that integrates the gut and central nervous system (CNS) activities, and thus the concept of microbiome–gut–brain axis is emerging."
So state researchers from the Department of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College.
Click here to read the abstract of their study published in December, 2013 in the journal, "Brain, Behavior and Immunity."
All in all, the gut is a terrific place to start helping humans be as healthy, resilient, and robust as we have evolved to be.
What do they have to do with psychiatry? It turns out way more than we might have suspected. The gut and brain have a steady ability to communicate via the nervous system, hormones, and the immune system. Some of the microbiome can release neurotransmitters, just like our own neurons do, speaking to the brain in its own language via the vagus nerve.
To have a full understanding of how the whole gut-brain connection works, you need robust knowledge of endocrinology, immunology, pathology, and neurology, which is a bit beyond the scope of a blog article. However, to break it down to simplistic terms, here are the basic links:"
Germ theory is dead. We are more germ than human.
Click here to read the entire article by Dr. Emily Deans published on the website of "Psychology Today" in April, 2014.
"Mammals live in a co-evolutionary association with the plethora of microorganisms that reside at a variety of tissue microenvironments. The microbiome represents the collective genomes of these co-existing microorganisms, which is shaped by host factors such as genetics and nutrients but in turn is able to influence host biology in health and disease. Niche-specific microbiome, prominently the gut microbiome, has the capacity to effect both local and distal sites within the host. The gut microbiome has played a crucial role in the bidirectional gut–brain axis that integrates the gut and central nervous system (CNS) activities, and thus the concept of microbiome–gut–brain axis is emerging."
So state researchers from the Department of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College.
Click here to read the abstract of their study published in December, 2013 in the journal, "Brain, Behavior and Immunity."
1 Course of Antibiotics Destroys Microbiome for One Year, Affects Cancer Treatment
The balance of good vs. bad bacteria – and even our understanding of how important this”bad” bacteria truly is – has shifted considerably in the past decade. Now a new scientific study is driving this point home by proving that gut bacteria can be the deciding factor in the success of new cancer therapies.
Click here to read the article on how the balance of the microbiome affects cancer treatment.
Click here to read the abstract of the study by a team of dozens of researchers from around the world. Their findings were published in November, 2015 in the journal, "Science."
Click here to read the article on how the balance of the microbiome affects cancer treatment.
Click here to read the abstract of the study by a team of dozens of researchers from around the world. Their findings were published in November, 2015 in the journal, "Science."
Psychological Conditions Relate to Microbiome
"These changes in myelin and activity-related gene expression could be reversed by colonization with a conventional microbiota following weaning.
In summary, we believe we demonstrate for the first time that the microbiome is necessary for appropriate and dynamic regulation of myelin-related genes with clear implications for cortical myelination at an ultrastructural level.
The microbiota is therefore a potential therapeutic target for psychiatric disorders involving dynamic myelination in the pre frontal cortex."
Click here to read the study by researchers from Ireland published in February, 2016 in the journal, "Translational Psychiatry."
Click here to read an article about the study in the Guardian.
Click here to read an article in the Atlantic Monthly magazine discussing and citing the work on the subject by researchers at Cal Tech among others.
In summary, we believe we demonstrate for the first time that the microbiome is necessary for appropriate and dynamic regulation of myelin-related genes with clear implications for cortical myelination at an ultrastructural level.
The microbiota is therefore a potential therapeutic target for psychiatric disorders involving dynamic myelination in the pre frontal cortex."
Click here to read the study by researchers from Ireland published in February, 2016 in the journal, "Translational Psychiatry."
Click here to read an article about the study in the Guardian.
Click here to read an article in the Atlantic Monthly magazine discussing and citing the work on the subject by researchers at Cal Tech among others.
Documentary film makers interview leading microbiome experts
"Babies that are born vaginally are first colonized by the bacteria from the mother's vaginal tract..."
"New bacteria and new foods are introduced by breast milk and its all a self supporting system..."
"Our microbiome doesn't start to stabilize until we're two or three years old..."
"Any interruption during that period is likely to have lifelong consequences..."
"Links are emerging between childhood diseases and imbalances in the microbiome..."
Click here to watch the trailer for a film about the microbiome in which they interview leading university professors and researchers into the emerging field of the microbiome.
"New bacteria and new foods are introduced by breast milk and its all a self supporting system..."
"Our microbiome doesn't start to stabilize until we're two or three years old..."
"Any interruption during that period is likely to have lifelong consequences..."
"Links are emerging between childhood diseases and imbalances in the microbiome..."
Click here to watch the trailer for a film about the microbiome in which they interview leading university professors and researchers into the emerging field of the microbiome.
Vaccines Interact With Microbiome, Researchers Are Just Now Discovering
"TLR5-mediated sensing of flagellin promoted plasma cell differentiation directly and by stimulating lymph node macrophages to produce plasma cell growth factors. Finally, TLR5-mediated sensing of the microbiota also impacted antibody responses to the inactivated polio vaccine, but not to adjuvanted vaccines or the live-attenuated yellow fever vaccine. These results reveal an unappreciated role for gut microbiota in promoting immunity to vaccination."
Click here to read the study published in 2014 in the journal, "Immunity."
Click here to read the study published in 2014 in the journal, "Immunity."