Polysorbate
Specific role of polysorbate 80 coating on the targeting of nanoparticles to the brain.
Polysorbate 80, brand name Tween 80 (T-80), is used in many vaccines. It is known to specifically target the brain. This is relevant as it can increase the toxicity of other vaccine components it is bound to.
From lab studies published in the journal, "Biomaterials," in 2004:
"Partial coverage was enough for T-80 coating to play a specific role in brain targeting. It seemed that brain targeting of nanoparticles was concerned with the interaction between T-80 coating and brain micro-vessel endothelial cells. Therefore, the specific role of T-80 coating on nanoparticles in brain targeting was confirmed."
Click here to read the abstract of this study.
From lab studies published in the journal, "Biomaterials," in 2004:
"Partial coverage was enough for T-80 coating to play a specific role in brain targeting. It seemed that brain targeting of nanoparticles was concerned with the interaction between T-80 coating and brain micro-vessel endothelial cells. Therefore, the specific role of T-80 coating on nanoparticles in brain targeting was confirmed."
Click here to read the abstract of this study.
Polysorbate 80 Causes Anaphylactic Shock
"Polysorbate 80 was identified as the causative agent for the anaphylactoid reaction of nonimmunologic origin in the patient.
Polysorbate 80 is a ubiquitously used solubilizing agent that can cause severe nonimmunologic anaphylactoid reactions."
Click here to read the abstract of the study by scientists in the Department of Dermatology, Friedrich-Alexander University in Germany. They published their findings in December, 2005 in the "Annals of Allergy, Asthma and Immunology."
Polysorbate 80 is a ubiquitously used solubilizing agent that can cause severe nonimmunologic anaphylactoid reactions."
Click here to read the abstract of the study by scientists in the Department of Dermatology, Friedrich-Alexander University in Germany. They published their findings in December, 2005 in the "Annals of Allergy, Asthma and Immunology."
Polysorbate 80 Contributes to Infertility
"Treatment with Tween 80 accelerated maturation, prolonged the oestrus cycle, and induced persistent vaginal oestrus. The relative weight of the uterus and ovaries was decreased relative to the untreated controls. Squamous cell metaplasia of the epithelial lining of the uterus and cytological changes in the uterus were indicative of chronic oestrogenic stimulation. Ovaries were without corpora lutea, and had degenerative follicles."
Click here to read the abstract of the study by researchers at the Institute of Preventive and Clinical Medicine in Bratislava. They published their findings in March, 1993 in the journal, "Food and Chemical Toxicology."
Click here to read the abstract of the study by researchers at the Institute of Preventive and Clinical Medicine in Bratislava. They published their findings in March, 1993 in the journal, "Food and Chemical Toxicology."
